Associate Director, Clinical Operations

Job Title: Associate Director, Clinical Operations
Company: Biopharma
Location: San Diego, CA (On-site)

Brio Resource Group is a Life Sciences Executive Search Firm committed to providing rare talent on an exclusive search basis to the Biopharma, Pharma, Device, and CRO industries. We work on behalf of organizations that value true talent acquisition partners and specialize in supporting emerging Biopharma companies offering life-changing therapies. Our many years of experience, subject matter expertise, comprehensive search process, and genuine passion to deliver rare talent defines Brio.

Position Overview:
We’re supporting a clinical-stage oncology biotech in San Diego in their search for an Associate Director, Clinical Operations to lead early-phase clinical programs in PSMA-targeted therapies. This is a pivotal role overseeing the end-to-end management of complex clinical trials, with a focus on vendor oversight, site engagement, and operational excellence.

Opportunity Highlights:

  • Lead the operational execution of Phase I oncology clinical trials

  • Serve as primary sponsor lead overseeing CROs and vendors

  • Develop strong partnerships with clinical sites and vendors to ensure timely, compliant study conduct

  • Contribute to protocol design, site feasibility, ICF development, and clinical document management

  • Drive study startup, enrollment tracking, data review, and risk management activities

  • Oversee budget and invoice reconciliation, vendor SOWs, and trial master file (TMF) oversight

  • Represent Clinical Operations in cross-functional meetings and provide updates to senior leadership

  • Ensure inspection readiness, manage audit preparation, and support regulatory submissions

  • Mentor junior staff and contribute to SOP development and best practice sharing

Position Requirements:

  • Bachelor’s degree in a scientific or healthcare field required

  • 10–12 years of clinical research experience with 6+ years directly managing oncology trials

  • Must have hands-on experience running trials from initiation through close-out

  • Demonstrated expertise in solid tumors, immunotherapies, or biologics is strongly preferred

  • Strong grasp of ICH GCP, FDA, and global regulatory requirements

  • Proven ability to lead vendor and site oversight activities independently

  • Skilled in using clinical trial systems and tools, including CTMS, eTMF, and EDC platforms

  • Strong communication, leadership, and organizational abilities

  • Comfortable working in a dynamic, cross-functional environment with a high sense of ownership

We welcome the opportunity to provide a full job description upon resume review.