Principal Scientist, Pharmacology
Principal Scientist, Pharmacology
Company: Commercial-Stage Biotechnology Company
Location: Philadelphia, PA
Engagement: Contract Consulting Role
The Opportunity
Brio Resource Group is partnering with a high-growth biotechnology company developing innovative oncology therapies to hire a Principal Scientist, Pharmacology.
This consulting engagement will provide hands-on pharmacology expertise supporting discovery and preclinical development programs. The successful consultant will design and execute studies to establish biological activity, evaluate mechanism of action, and generate the evidence needed to guide candidate selection and program investment decisions.
Key Responsibilities
- Design and execute in vitro and in vivo pharmacology studies using fit-for-purpose disease models.
- Evaluate efficacy, target engagement, pharmacodynamic activity, and mechanism-of-action hypotheses.
- Select and optimize preclinical models aligned with program objectives and translational strategy.
- Analyze and interpret complex experimental data and recommend follow-up studies or program decisions.
- Translate pharmacology findings into clear, actionable recommendations for multidisciplinary project teams.
- Partner with Biology, Chemistry, DMPK, Toxicology, Translational Sciences, and other research functions.
- Support candidate selection, biomarker, and translational research activities.
- Coordinate studies with CROs, academic collaborators, and external research partners.
- Ensure experimental quality, reproducibility, appropriate controls, and complete study documentation.
- Communicate findings through research reports, presentations, and cross-functional program reviews.
Qualifications
- PhD or equivalent advanced research expertise in pharmacology, cancer biology, molecular biology, or a related discipline.
- Significant biotechnology or pharmaceutical experience designing and executing preclinical pharmacology studies.
- Hands-on experience developing disease models and evaluating preclinical efficacy.
- Strong understanding of target validation, mechanism of action, target engagement, and pharmacodynamic endpoints.
- Demonstrated ability to integrate pharmacology findings with DMPK, toxicology, biomarker, and translational data.
- Strong experimental design, quantitative analysis, data interpretation, and scientific communication skills.
- Experience managing external laboratories, CROs, or academic research collaborations.
- Experience supporting oncology drug discovery, candidate selection, or IND-enabling programs is preferred.
- Ability to work independently while collaborating effectively within multidisciplinary research teams.
Why Consider This Opportunity?
This engagement offers the opportunity to contribute directly to high-priority oncology research programs, combine hands-on experimental work with senior scientific judgment, and generate evidence that influences which therapeutic candidates advance toward clinical development.
Additional information regarding the company, contract duration, weekly allocation, compensation, and working arrangement will be provided following an initial résumé review.
