Senior Clinical Trial Manager

Company: High-Growth Biopharmaceutical Company
Location: Remote, United States
Work Arrangement: Remote
Engagement: Contract Consulting Role

The Opportunity

Brio has partnered with a high-growth biopharmaceutical company to recruit a Senior Clinical Trial Manager. This consultant will lead day-to-day execution of assigned clinical studies, coordinating internal teams, CROs, sites, and specialized vendors to keep progress on track against key milestones.

The role requires a hands-on clinical operations professional who can maintain visibility across study timelines, budgets, enrollment, data quality, vendor performance, and emerging risks while driving timely decisions and follow-through.

Key Responsibilities

• Lead operational execution of assigned clinical studies from planning and start-up through database lock and closeout.
• Develop and maintain study plans, timelines, budgets, risk registers, and operational tracking tools.
• Coordinate cross-functional study teams and facilitate meetings, decisions, action items, and issue resolution.
• Oversee CROs and clinical vendors, monitoring performance against contractual commitments, timelines, quality standards, and budgets.
• Support site feasibility, selection, activation, enrollment, monitoring, and closeout activities.
• Track recruitment and enrollment performance and implement mitigation plans when studies fall behind.
• Partner with Data Management, Biometrics, Clinical Development, Safety, Regulatory Affairs, Quality, and Supply Chain.
• Contribute to protocols, informed consent forms, study manuals, monitoring plans, and other operational documents.
• Support data review, query resolution, data cleaning, and database-lock readiness.
• Identify and escalate study risks while leading corrective and preventive actions.
• Ensure study conduct complies with protocols, ICH-GCP, applicable regulations, and company procedures.
• Maintain inspection-ready study documentation and support audit and regulatory inspection activities.

Qualifications

• Bachelor’s degree in life sciences, nursing, pharmacy, or a related discipline; advanced education is beneficial.
• Significant clinical trial management experience within a biotechnology, pharmaceutical, or CRO environment.
• Demonstrated experience independently managing clinical studies and outsourced service providers.
• Strong understanding of study start-up, enrollment, site management, monitoring, data cleaning, and closeout activities.
• Experience managing study timelines, budgets, vendors, risks, and cross-functional deliverables.
• Comprehensive knowledge of ICH-GCP and applicable global regulatory requirements.
• Strong organizational, communication, problem-solving, and stakeholder-management capabilities.
• Ability to work independently and maintain execution momentum within a remote, cross-functional environment.
• Sponsor-side experience supporting late-stage, global, or registration-directed studies is preferred.
• Experience in metabolic, hepatology, cardiovascular, or related therapeutic areas is beneficial.

Why Consider This Opportunity?

• Study ownership: Lead operational delivery across a clearly defined clinical trial scope.
• Cross-functional influence: Partner with clinical, scientific, regulatory, data, safety, and quality stakeholders.
• Execution impact: Remove barriers affecting enrollment, quality, timelines, and milestone delivery.
• Portfolio visibility: Support important clinical programs within a growing biopharmaceutical organization.
• Remote flexibility: Contribute at a senior level through a fully remote consulting engagement.

Interested?

Submit your resume to Brio to learn more about the organization, its clinical programs, and the consulting engagement. Additional details on contract duration, allocation, compensation, and the full job description will be provided after an initial resume review.

Brio Resource Group partners with emerging and high-growth life sciences companies to recruit executives, functional leaders, and specialized professionals.